Oral vs Injectable Methotrexate
Learn the differences between oral methotrexate and injectable methotrexate, such as an auto-injector or a syringe and vial option.
Methotrexate is absorbed differently depending on the delivery
Drugs need to be absorbed into the body before they can go where they are needed. Oral drugs are absorbed through your stomach and small intestine. As a result, the drugs may be absorbed poorly into the body.
Drugs that are injected under the skin—such as Rasuvo—do not have to go through the stomach to be absorbed.
Why is this important? Basically, patients may experience fewer gastrointestinal (GI) side effects and have a better response to treatment with Rasuvo than with oral methotrexate. A recent study showed that healthy people who were given Rasuvo absorbed more methotrexate than did those who were given methotrexate tablets. In this study, people who were given Rasuvo had fewer GI side effects.
This information doesn’t guarantee that Rasuvo will work better and have fewer GI side effects in patients. However, it may explain why some patients taking Rasuvo experience greater control of symptoms and fewer GI side effects than patients taking oral methotrexate. Talk to your doctor about Rasuvo to see if it is right for you.
Download a patient brochure to learn more.