Learn the differences between oral methotrexate and injectable methotrexate, such as an auto-injector or a syringe and vial option.
|Oral methotrexate||Auto-injector methotrexate||Syringe and vial methotrexate|
|How to take||A pill taken by mouth||A prefilled single-dose device that allows the drug to be injected manually under the skin||Methotrexate liquid drawn from a vial into a single-use syringe that can then be injected manually under the skin|
|Ease of use||Taken by mouth; swallowed with liquid||Prefilled and ready to use, requires fewer steps than a vial and syringe||More steps are required than with a pill or with an auto-injector. The vial top must be cleaned with an alcohol swab. The drug must be precisely measured and drawn into a single-use manually under the skin.|
|Portable||Yes||Yes||Yes. However, more items are required for administration than with oral methotrexate or with an auto-injector.|
|Safeguard||N/A||The needle shield on the Rasuvo® (methotrexate) injection device minimizes the potential for needle injuries.||The needle of the syringe is exposed, increasing the potential for needle injuries.|
Drugs need to be absorbed into the body before they can go where they are needed. Oral drugs are absorbed through your stomach and small intestine. As a result, the drugs may be absorbed poorly into the body.
Drugs that are injected under the skin—such as Rasuvo—do not have to go through the stomach to be absorbed.
Why is this important? Basically, patients may experience fewer gastrointestinal (GI) side effects and have a better response to treatment with Rasuvo than with oral methotrexate. A recent study showed that healthy people who were given Rasuvo absorbed more methotrexate than did those who were given methotrexate tablets. In this study, people who were given Rasuvo had fewer GI side effects.
This information doesn’t guarantee that Rasuvo will work better and have fewer GI side effects in patients. However, it may explain why some patients taking Rasuvo experience greater control of symptoms and fewer GI side effects than patients taking oral methotrexate. Talk to your doctor about Rasuvo to see if it is right for you.
Download a patient brochure to learn more.
Rasuvo (methotrexate) injection is a single-dose auto-injector containing a prescription medicine, methotrexate. Methotrexate is used to:
Rasuvo should not be used for the treatment of cancer.
Rasuvo should not be used for the treatment of children with psoriasis.
Rasuvo is available in doses of 7.5, 10, 12.5, 15, 17.5, 20, 22.5, 25, 27.5, and 30 mg. Your doctor will prescribe a different way to take methotrexate if you need to take methotrexate by mouth or in some other way.
Common side effects of Rasuvo include: nausea, stomach pain, indigestion (dyspepsia), mouth sores, and rash.
Do not take Rasuvo if you:
Before you take Rasuvo, tell your doctor if you have any other medical conditions. Tell your doctor about all of the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.
Rasuvo may affect how other medicines work, and other medicines may affect how Rasuvo works, causing side effects. Ask your doctor or pharmacist for a list of medicines if you are not sure.
Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Rasuvo. For more information, ask your doctor or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.