Prescription Savings


Methotrexate Patient Resources



Get the support you need

Call Benefits Support 1-855-33MEDAC (6-3322)
for reimbursement services/patient eligibility
Mon-Fri, 8:00 am to 8:00 pm EST

Get support for your prescription—we are here to help. Assistance and financial support are available through CORE Connections, the Rasuvo® (methotrexate) injection Patient Program.
Learn more about the available financial resources below.

Co-pay Assistance Program

The co-pay assistance program provides financial support of up to $125 per month for up to 12 months. Eligibility restrictions apply.

Sign up here or call 1-855-33MEDAC (6-3322).


for co-pay assistance.

Rasuvo Insurance

Call the Benefits Support helpline at 1-855-33MEDAC (6-3322).

For reimbursement services and patient eligibility determinations,
call 8:00 am to 8:00 pm EST, Monday-Friday (excluding holidays).

The Benefits Support helpline is available to help you and your healthcare professional with

  • Reimbursement questions
  • Insurance verification and help with prior authorizations
  • Information about co-pay and patient eligibility
  • Assistance with applications and requests for the Patient Assistance Program
MTX Patient Assistance Program

Patient Assistance Program

Download the Patient Assistance Program application.

Medac Pharma, Inc., is committed to helping patients afford their Rasuvo medication. The Patient Assistance Program is available to qualifying patients for ongoing Rasuvo use, as directed by a healthcare provider. Approved patients have an enrollment duration of 1 year, after which they may apply again.

To learn more,
call our Benefits Support helpline at 1-855-33MEDAC (6-3322).
Other terms and conditions may apply.

Personalized Pharmacy Support

Personalized Pharmacy Support provides eligible patients with assistance in obtaining Rasuvo through a pharmacy partner. With this service, you can receive your Rasuvo prescription via an overnight delivery service.

Call our Pharmacy Support helpline at 1-855-MEDAC (6-3322 ) to learn more.
Other terms and conditions may apply.

Methotrexate doctor forms

Dose Modification Program

Ask your doctor about the Rasuvo Dose Modification Program. This program offers financial assistance to certain patients as the appropriate dose of Rasuvo is being determined.

Download and give this form to your healthcare professional. Your healthcare professional will fax the completed form to (800) 582-0022.


Indications, Important Safety Information, Including Boxed Warning

What is Rasuvo® (methotrexate) injection?

Rasuvo is a single-dose auto-injector containing a prescription medicine, methotrexate. Methotrexate is used to:

  • Treat certain adults with severe, active rheumatoid arthritis, and children with active polyarticular juvenile idiopathic arthritis (pJIA), after treatment with other medicines including non-steroidal anti-inflammatory (NSAIDS) have been used and did not work well.
  • Control the symptoms of severe, resistant, disabling psoriasis in adults when other types of treatment have been used and did not work well.

Rasuvo should not be used for the treatment of cancer.

Rasuvo should not be used for the treatment of children with psoriasis.

Rasuvo is available in doses of 7.5, 10, 12.5, 15, 17.5, 20, 22.5, 25, and 30 mg. Your doctor will prescribe a different way to take methotrexate if you need to take methotrexate by mouth or in some other way.

Important Safety Information, Including Boxed Warning, for Rasuvo

What is the most important information I should know about Rasuvo?

This product includes the following Boxed Warning:

Rasuvo can cause serious side effects that can lead to death, including:

Organ system toxicity. People who use methotrexate for the treatment of cancer, psoriasis, or rheumatoid arthritis, have an increased risk of death from organ toxicity. Types of organ toxicity can include: gastrointestinal, nerve, bone marrow, lung, liver, kidneys, immune system, and skin.

Your doctor will do blood tests and other types of tests before you take and while you are taking Rasuvo to check for signs and symptoms of organ toxicity. Call your doctor right away if you have any of the following symptoms of organ toxicity: vomiting, neck stiffness, diarrhea, paralysis, mouth sores, irritability, fever, sleepiness, confusion, problems with coordination, weakness, dry cough, temporary blindness, trouble breathing, seizures, severe skin rash, headache, and back pain.

Women who are pregnant are at increased risk for death of the baby and for birth defects in the baby. Women who are pregnant or who plan to become pregnant must not take Rasuvo. A pregnancy test should be performed before starting Rasuvo. Contraception should be used by both females and males while taking Rasuvo. Pregnancy should be avoided if either partner is receiving Rasuvo:

  • – for a minimum of 3 months after treatment with Rasuvo for males.
  • – during and for at least 1 menstrual cycle after treatment with Rasuvo for females.

What are the possible side effects of Rasuvo?

Rasuvo may cause serious side effects, including:

  • Fertility problems. Methotrexate, the active ingredient in Rasuvo, may affect your ability to have a baby. Males may have a decreased sperm count, and females may have changes to their menstrual cycle. This can happen while taking Rasuvo and for a short period of time after you stop.
  • Certain cancers. Some people who have taken methotrexate have had a certain type of cancer called Non-Hodgkin's lymphoma and other tumors. Your doctor may tell you to stop taking Rasuvo if this happens.
  • Tissue and bone problems. Taking methotrexate while having radiation therapy may increase the risk of your tissue or bone not receiving enough blood. This may lead to death of the tissue or bone.

Common side effects of Rasuvo include: nausea, stomach pain, indigestion (dyspepsia), mouth sores, and rash.

Who should not take Rasuvo?

Do not take Rasuvo if you:

  • Are pregnant or planning to become pregnant
  • Are breastfeeding; Rasuvo can pass into your breast milk and may harm your baby.
  • Have alcohol problems (alcoholism)
  • Have liver problems
  • Have problems fighting infection (immunodeficiency syndrome)
  • Have been told you have (or think you have) a blood disorder, such as low levels of white blood cells, red blood cells (anemia), or platelets
  • Have had an allergy to methotrexate or any of the ingredients in Rasuvo

What should I tell my doctor before taking Rasuvo?

Before you take Rasuvo, tell your doctor if you have any other medical conditions. Tell your doctor about all of the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

Rasuvo may affect how other medicines work, and other medicines may affect how Rasuvo works, causing side effects. Ask your doctor or pharmacist for a list of medicines if you are not sure.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Rasuvo. For more information, ask your doctor or pharmacist.

For additional information about Rasuvo, please refer to the Patient Information Leaflet and Instructions for Use, which can be found at or call 1-855-33MEDAC (1-855-336-3322).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.