Patient Savings and Assistance

Co-pay assistance program

Did you know that 85% of patients who used the Rasuvo® (methotrexate) injection co-pay card had a $0 co-pay?* With the co-pay card you could save up to $125 per month for up to 14 months.

Savings card

Rasuvo has the broadest insurance coverage

  • CVS Caremark®
  • Express Scripts®
  • Humana®
  • Cigna®
  • UnitedHealth Group®
  • Highmark Health®
  • HCSC®
  • Anthem®
  • OptumRx®
  • Preferred
  • Covered
Download the co-pay card

CORE Connections

Get prescription assistance and financial support through CORE Connections, the Rasuvo patient program. Call CORE Connections at 1-855-336-3322, from 8:00 am to 8:00 pm EST Monday-Friday (excluding holidays).

  • Personalized Support—Our support team can help determine your insurance coverage for Rasuvo, review eligibility for financial assistance, and help complete applications for financial support. Representatives are available from 8:00 am to 8:00 pm EST Monday-Friday (excluding holidays).
  • Patient Assistance Program—You may be eligible to receive financial support for your Rasuvo prescription. Download the Patient Assistance Program application and bring it to your prescribing physician to help you complete.
Core Connections

Dose modification program

If your doctor needs to adjust the dose of Rasuvo before you are due for a refill, you may benefit from the Rasuvo dose modification program.

Download and give this form to your healthcare professional to save money on your new prescription.

*Data from April 2016 to April 2017.

Restrictions apply.

Average nationwide coverage of methotrexate auto-injectors. Individual coverage may vary.

All brand or product names are registered trademarks of their respective owners.

What is Rasuvo® (methotrexate) injection?

Rasuvo is a single-dose auto-injector containing a prescription medicine, methotrexate. Methotrexate is used to:

Rasuvo should not be used for the treatment of cancer.

Rasuvo should not be used for the treatment of children with psoriasis.

Rasuvo is available in doses of 7.5, 10, 12.5, 15, 17.5, 20, 22.5, 25, and 30 mg. Your doctor will prescribe a different way to take methotrexate if you need to take methotrexate by mouth or in some other way.

Important Safety Information, Including Boxed Warning, for Rasuvo

What is the most important information I should know about Rasuvo?

This product includes the following Boxed Warning:

Rasuvo can cause serious side effects that can lead to death, including:

Organ system toxicity. People who use methotrexate for the treatment of cancer, psoriasis, or rheumatoid arthritis, have an increased risk of death from organ toxicity. Types of organ toxicity can include: gastrointestinal, nerve, bone marrow, lung, liver, kidneys, immune system, and skin.

Your doctor will do blood tests and other types of tests before you take and while you are taking Rasuvo to check for signs and symptoms of organ toxicity. Call your doctor right away if you have any of the following symptoms of organ toxicity: vomiting, neck stiffness, diarrhea, paralysis, mouth sores, irritability, fever, sleepiness, confusion, problems with coordination, weakness, dry cough, temporary blindness, trouble breathing, seizures, severe skin rash, headache, and back pain.

Women who are pregnant are at increased risk for death of the baby and for birth defects in the baby. Women who are pregnant or who plan to become pregnant must not take Rasuvo. A pregnancy test should be performed before starting Rasuvo. Contraception should be used by both females and males while taking Rasuvo. Pregnancy should be avoided if either partner is receiving Rasuvo:

  • for a minimum of 3 months after treatment with Rasuvo for males.
  • during and for at least 1 menstrual cycle after treatment with Rasuvo for females.

What are the possible side effects of Rasuvo?

Rasuvo may cause serious side effects, including:

  • Fertility problems. Methotrexate, the active ingredient in Rasuvo, may affect your ability to have a baby. Males may have a decreased sperm count, and females may have changes to their menstrual cycle. This can happen while taking Rasuvo and for a short period of time after you stop.
  • Certain cancers. Some people who have taken methotrexate have had a certain type of cancer called Non-Hodgkin’s lymphoma and other tumors. Your doctor may tell you to stop taking Rasuvo if this happens.
  • Tissue and bone problems. Taking methotrexate while having radiation therapy may increase the risk of your tissue or bone not receiving enough blood. This may lead to death of the tissue or bone.

Common side effects of Rasuvo include: nausea, stomach pain, indigestion (dyspepsia), mouth sores, and rash.

Who should not take Rasuvo?

Do not take Rasuvo if you:

What should I tell my doctor before taking Rasuvo?

Before you take Rasuvo, tell your doctor if you have any other medical conditions. Tell your doctor about all of the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

Rasuvo may affect how other medicines work, and other medicines may affect how Rasuvo works, causing side effects. Ask your doctor or pharmacist for a list of medicines if you are not sure.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Rasuvo. For more information, ask your doctor or pharmacist.

For additional information about Rasuvo, please refer to the Patient Information Leaflet and Instructions for Use, which can be found at or call 1-855-336-3322.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.